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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
19.39
Human Site:
S174
Identified Species:
47.41
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
S174
A
K
S
S
S
K
E
S
R
S
S
K
L
H
K
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
A171
A
A
T
A
A
T
A
A
G
G
T
G
G
S
G
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
S174
A
K
S
S
S
K
E
S
R
S
S
K
L
H
K
Dog
Lupus familis
XP_548147
1490
164467
S175
K
S
S
S
N
K
E
S
R
S
S
K
L
H
K
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
S173
S
K
S
G
S
K
E
S
R
S
S
K
M
H
K
Rat
Rattus norvegicus
Q3MJK5
1484
163772
S173
S
K
S
S
S
K
E
S
R
S
S
K
M
H
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
K53
S
S
R
R
K
R
H
K
R
G
R
E
K
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
H228
E
I
I
I
S
P
E
H
E
K
P
V
G
N
W
Nematode Worm
Caenorhab. elegans
P46551
730
82410
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
S31
K
R
K
H
A
K
S
S
K
S
G
R
H
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
6.6
100
80
N.A.
80
86.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
13.3
0
20
P-Site Similarity:
100
40
100
86.6
N.A.
93.3
100
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
20
0
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
10
0
10
20
0
10
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
0
0
60
0
10
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
10
20
10
10
20
0
10
% G
% His:
0
0
0
10
0
0
10
10
0
0
0
0
10
50
0
% H
% Ile:
0
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
20
40
10
0
10
60
0
10
10
10
0
50
10
10
50
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
30
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
10
10
10
0
10
0
0
60
0
10
10
0
0
0
% R
% Ser:
30
20
50
40
50
0
10
60
0
60
50
0
0
10
10
% S
% Thr:
0
0
10
0
0
10
0
0
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _